SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY (LEIGH'S DISEASE)
نویسندگان
چکیده
منابع مشابه
MR of Leigh's disease (subacute necrotizing encephalomyelopathy).
MR images of three patients with Leigh's disease (subacute necrotizing encephalomyelopathy) were compared with CT findings. In all patients typical lesions in the basal ganglia were identified with both MR and CT. In two patients MR permitted identification of additional lesions not detected with CT. In one patient progression of MR abnormalities over a 4-month period correlated well with clini...
متن کاملSubacute necrotizing encephalomyelopathy in an infant.
K.H., a boy, aged 7 months 3 weeks, was admitted to King's College Hospital on April 22, 1947. Birth had been normal (birth weight 63 lb.) as also was development until six weeks before admission. The infant was vaccinated at the age of 2 months. He was breast-fed entirely for six weeks, then complementary feeding was begun. The baby's behaviour was normal until six weeks before admission when ...
متن کاملSubacute necrotising encephalomyelopathy (Leigh’s disease; Leigh syndrome)
Like so many complex and incurable neurological disorders, the disease first described in this journal in 1951 by (Archibald) Denis Leigh (1915–1998; figure 1) as ‘Subacute Necrotising Encephalomyelopathy’ (SNE) remained for many years a rare and intriguing enigma, of interest mainly to paediatric neurologists and neuropathologists. The more recent history of this disorder, now designated Leigh...
متن کاملLeigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.
The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly th...
متن کاملLeigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy
We report the untypical clinical course of a previously healthy two-year-old girl, who died suddenly and unexpectedly after an episode of vomiting. At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histologically they presented as areas of spongiosis of the neuropil with prominent endothelial hyperpl...
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ژورنال
عنوان ژورنال: Journal of Paediatrics and Child Health
سال: 1994
ISSN: 1034-4810,1440-1754
DOI: 10.1111/j.1440-1754.1994.tb00641.x